The beginning of the 21^st century saw numerous protein/ peptide and RNA therapeutics both in the market and entering the final stages of clinical studies. The main advantages of these biologics over conventional drugs can be summarized by their high selectivity and potent therapeutic efficacy coupled with limited side effects. In addition, they exhibit more predictable behavior under in vivo conditions. However, up to now most of the formulations of biologics are designed and destined for the parenteral route of administration. As a consequence, many suffer from short plasma half-lives, resulting in their frequent administration and ultimately poor patient compliance. To address this shortcoming, researchers in both academia and industry started working on designing innovative encapsulation or delivery platforms for biologics especially after the recent pandemic. Similarly, a delivery challenge is seen in agricultural practices where huge amounts of pesticides and fertilizers are used in light of the need to meet the increasing food demands and improve nutritional content. In this talk, a new generation of smart encapsulation platforms based on reticular and supramolecular chemistry will be presented. These systems have shown superiority in encapsulating and protecting biological cargoes and nutrients with different size, charge, and solubility profile. We envision that this class of molecules can efficiently address many practical challenges in the field of encapsulation and controlled delivery and so can easily undergo translational scale up to be used in the market.