Klebsiella pneumoniae is a major bacterial pathogenic strain, which underlies clinical infections worldwide. The recent emergence of hypervirulent and antibiotic-resistant strains has been recognized as an imminent issue worldwide and in Saudi Arabia. In this talk, I will present a recent genomic survey to demonstrate the emergence of hypervirulent and multidrug-resistant clones within the Saudi clinical setting at a high resolution. By applying a broad range of genomic epidemiology and data analysis methods, we have shown how the clone rapidly emerged on epidemiological time scales. This concurrently occurred with the acquisition of resistance determinants and the convergence of virulence and resistance genes, leading to the formation of hypervirulent multidrug-resistant strains. The results highlight the clinical importance and the risk of emerging K. pneumoniae strains.