Principal Investigator: Prof. Sahika Inal

Poster Presenter: Bayan Almarhoon

Lab: Organic Bioelectronics Laboratory

Electrochemical device for the detection of Alzheimer’s disease protein markers




Alzheimer's disease (AD) is a neurodegenerative disorder that causes progressive cognitive impairment and memory loss in one out of every ten people over the age of 65. AD is not curable yet, and treatment may be ineffective if identified later in the disease’s progression. Early detection is imperative to improving the efficiency of existing treatment, delaying or slowing symptoms, and thus providing the patient a better quality of life while navigating the disease. Electrochemical sensing is a promising approach for early detection of AD [1,2]. In our previous work, we developed an organic electrochemical transistor for the detection of Amyloid protein aggregates. In this work, we present an electrochemical sensor design capable of detecting proteins (i.e., glial fibrillary acidic protein (GFAP)), recently shown to exist in high concentrations in the blood of patients with AD [3].