Principal Investigator: Prof. Bruno Reversade
Poster Presenter: Aisha Saleem
Lab: Laboratory of human genetics and therapeutics
The activation of the NLRP1 complex is essential to maintain innate immunity. However, its aberrant functioning can lead to chronic localised and systemic inflammation. Thus, there exist multiple endogenous mechanisms to keep NLRP1 in check. Alternative splicing of NLRP1 results in multiple distinct isoforms whose function is currently unknown. Tissue expression data leads us to assume a vital role of these spliced isoforms in modulating inflammatory response via autoinhibition. Thus, we aim at understanding the role of alternatively spliced isoforms of NLRP1 and identifying therapeutic strategies involving these potential modulators.