Proof of Concept projects

HLA-Based Banking of iPS cells and the

KAUST PI(s): Jesper Tegner Collaborative Institution: KAIMRC (NGHA) Collaboration Partner(s): Dr. Khaled Alsayegh

Defining epigenetic regulatory mechanisms of human heat stress response with and without heatstroke

KAUST PI(s): Wolfgang Fischle Collaborative Institution: KAIMRC (NGHA) Collaboration Partner(s): Mamoon Rashid, Abderrazaq Bouchama

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Development of Machine Learning Algorithm for Differentiation of Lung Cancer Subtypes

KAUST PI(s): Peter Wonka Collaborative Institution: KAIMRC (NGHA) Collaboration Partner(s): Mohd Alawad, Hussein Mohd, Abdulrahman Aljouie, Yaha Bukhari

Integrative Rare Loss of function (LOF) Variant Analysis for hundreds of phenotypes in the Saudi Population

KAUST PI(s): Stefan Arold (Xin Gao and Jesper Tegner) Collaborative Institution: KFSH&RC Collaboration Partner(s): Fowzan Sami Alkuraya

Computer-aided detection and diagnosis of atherosclerosis using signal processing and artificial intelligence methods

KAUST PI(s): Marium Laleg Collaborative Institution: KAIMRC (NGHA) Collaboration Partner(s): Ali Haneef

Implementation of Metagenomics Technologies to Revolutionize Solid Organ Transplantation: Toward a Safer Transplantation

KAUST PI(s): Arnab Pain Collaborative Institution: KFSH&RC Collaboration Partner(s): Reem Almaghrabi, Ahmed Alqahtani, Abdulraham Alrajhi

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Circulating miRNAs as Potential Diagnostic Biomarker for NAFLD/NASH related Hepatocellular Carcinoma (HCC) in Saudi Population

KAUST PI(s): Valerio Orlando Collaborative Institution: KFSH&RC Collaboration Partner(s): Samar Zailaie

Two combined projects: (1) Precise and Comprehensive NMR-based Metabolomics Profiling in Saudi Patients with known or suspected Inborn Errors of Metabolism (2) Establishing a novel NMR-based metabolomics platform for medical diagnostics with the enhancement of signals and resolution

KAUST PI(s): Mariusz Jaremko, Lukasz Jaremko Collaborative Institution: KFSH&RC Collaboration Partner(s): Majed Desouki

Glycosyltransferase gene expression profile as a predictor of clinical cancer type and survival

KAUST PI(s): Jasmeen Merzaban (Xin Gao) Collaborative Institution: KFSH&RC Collaboration Partner(s): Shahrukh Hashmi, Ali Alzahrani

Microbiomes in Health and Disease: the Saudi Perspective

KAUST PI(s): Arnab Pain (Daniele Daffonchio) Collaborative Institution: KFMR-KAU Collaboration Partner(s): Dr. Turki Abujamel

Developing a potent pharmacologic inhibitor of The Peroxisome Proliferator-Activated Receptor gamma-coactivator (PPRC1) for the treatment of drug resistant Myeloid Leukemia

KAUST PI(s): Magnus Rueping Collaborative Institution: KFSH&RC Collaboration Partner(s): Sayer Rashed Alharbi

An iPSC-based disease-modeling approach to study Klinefelter Syndrome in a unique cohort of Saudi patients

KAUST PI(s): Antonio Adamo Collaborative Institution: KAU Collaboration Partner(s): Taha Abdel Maguid, Majed Flemban, Amal Kokandi

Identification of the molecular mechanisms conferring protection from type two diabetes onset in a Saudi patient knock out for the glucagon-like peptide 1 receptor (GLP1R-/-)

KAUST PI(s): Antonio Adamo / Mo Li Collaborative Institution: KFSH&RC Collaboration Partner(s): Fowzan Sami Alkurya

Potential role and therapeutic targeting of Repetitive Elements In Ageing associated Cardiovascular Disease

KAUST PI(s): Valerio Orlando Collaborative Institution: KFSH&RC Collaboration Partner(s): Olga Vriz, Gruschen R Veldtman

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Clinical and biochemical characterization of genetic diseases associated with neuron-glia metabolic interaction including lactate production and transporter defect in the nervous system

KAUST PI(s): Pierre Magistretti Collaborative Institution: King Saud University Medical City (KSUMC) Collaboration Partner(s): Malak Ali Alghamdi

Establishment of a Saudi cohort of iPSCs using genomic integration-free methods

KAUST PI(s): Mo Li and Antonio Adamo

Process Development and Production of Recombinant Influenza Surface Proteins as Alternatives to the Traditional Egg Derived Vaccines

KAUST PI(s): Stefan Arold Collaborative Institution: SaudiVax Collaboration Partner(s): Anwar Hashem

Exploring the Polygenic Risk Score (PRS) for Common Multifactorial Disorders in Saudi Arabia

KAUST PI(s): Xin Gao Collaborative Institution: KFSH&RC Collaboration Partner(s): Fowzan Sami Alkuraya

Maximize human perception of X-ray Images by using Computed tomography (CT)

KAUST PI(s): Wolfgang Heidrich Collaborative Institution: KAIMRC (NGHA) Collaboration Partner(s): Mohd Alawad, Mohd F.Mohammad, Abdulrahman Aljouie, Yaha Bukhari